Cholestyramine and Ziac

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Cholestyramine may interfere with the absorption of hydroCHLOROthiazide when these medications are taken at the same time. This may reduce the blood levels and effects of hydroCHLOROthiazide. To prevent or minimize the interaction, hydroCHLOROthiazide should be taken at least 1 to 2 hours before or 4 to 6 hours after the cholestyramine dose. Contact your doctor if your condition changes or your symptoms worsen during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Cholestyramine may decrease the gastrointestinal absorption of thiazide diuretics by binding them in the gut. The interaction has been studied with hydrochlorothiazide (HCTZ). In six healthy volunteers, administration of single 8 gm doses of cholestyramine 2 minutes before, then 6 and 12 hours after, a 75 mg oral dose of HCTZ reduced the total urinary excretion of HCTZ by 85%. Similar effects were also observed for plasma HCTZ levels. In another study, a single 8 gm dose of cholestyramine given 2 hours before or after a 75 mg dose of HCTZ reduced the 24-hour urinary excretion of unchanged HCTZ by 65% and 26%, respectively, in four subjects. A subsequent study in six subjects reported that the best dosing schedule for cholestyramine is 4 hours after HCTZ, although that would still reduce HCTZ absorption by 30% to 35%.

MANAGEMENT: Thiazide diuretics should be administered at least 1 to 2 hours before or 4 to 6 hours after cholestyramine administration. Patients should be monitored for potentially diminished therapeutic effects, and the thiazide dosage adjusted if necessary.

Cholestyramine

Generic Name: cholestyramine

Brand name: Cholestyramine Light, Prevalite, Questran, Questran Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets

Synonyms: Cholestyramine Resin

What is Cholestyramine?

Ziac

Generic Name: bisoprolol / hydrochlorothiazide

Brand name: Ziac

Synonyms: n.a.

What is Ziac?