Cholestyramine Light and Climara Pro transdermal
Determining the interaction of Cholestyramine Light and Climara Pro transdermal and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with bile-acid binding resins such as cholestyramine may decrease the plasma concentrations and therapeutic effects of estrogens and progestins. The proposed mechanism involves delaying or reducing the absorption of concomitant orally administered drugs by cholestyramine. In addition, it has also been suggested that bile-acid binding resins may interfere with the enterohepatic recycling of estrogens and therefore increase their elimination. MANAGEMENT: Estrogens and/or progestin-containing oral medications should be administered at least one hour before or four to six hours after bile-acid binding resins such as cholestyramine, colestipol, and colesevelam. Patients receiving this combination should be advised to closely follow dosing schedules to prevent loss of therapeutic effects. References "Product Information. Questran (cholestyramine)." Par Pharmaceutical Inc, Chestnut Ridge, NY. Underhill KL, Rotter BA, Thompson BK, Prelusky DB, Trenholm HL "Effectiveness of cholestyramine in the detoxification of zearalenone as determined in mice." Bull Environ Contam Toxicol 54 (1995): 128-34 Arts CJM, Govers CARL, van den Berg H, Wolters MGE, van Leeuwen P, Thijssen JHH "In vitro binding of estrogens by dietary fiber and the in vivo apparent digestibility tested in pigs." J Steroid Biochem Mol Biol 38 (1991): 621-8 Cerner Multum, Inc. "Australian Product Information." O 0 Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]): Cerner Multum, Inc. "Canadian Product Information." O 0 (2015): View all 6 references
Professional:MONITOR: Coadministration with bile-acid binding resins such as cholestyramine may decrease the plasma concentrations and therapeutic effects of estrogens and progestins. The proposed mechanism involves delaying or reducing the absorption of concomitant orally administered drugs by cholestyramine. In addition, it has also been suggested that bile-acid binding resins may interfere with the enterohepatic recycling of estrogens and therefore increase their elimination.
MANAGEMENT: Estrogens and/or progestin-containing oral medications should be administered at least one hour before or four to six hours after bile-acid binding resins such as cholestyramine, colestipol, and colesevelam. Patients receiving this combination should be advised to closely follow dosing schedules to prevent loss of therapeutic effects.
- "Product Information. Questran (cholestyramine)." Par Pharmaceutical Inc, Chestnut Ridge, NY.
- Underhill KL, Rotter BA, Thompson BK, Prelusky DB, Trenholm HL "Effectiveness of cholestyramine in the detoxification of zearalenone as determined in mice." Bull Environ Contam Toxicol 54 (1995): 128-34
- Arts CJM, Govers CARL, van den Berg H, Wolters MGE, van Leeuwen P, Thijssen JHH "In vitro binding of estrogens by dietary fiber and the in vivo apparent digestibility tested in pigs." J Steroid Biochem Mol Biol 38 (1991): 621-8
- Cerner Multum, Inc. "Australian Product Information." O 0
- Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
- Cerner Multum, Inc. "Canadian Product Information." O 0 (2015):
Generic Name: cholestyramine
Brand name: Cholestyramine Light, Prevalite, Questran, Questran Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets
Synonyms: n.a.
Generic Name: estradiol / levonorgestrel
Brand name: Climara Pro
Synonyms: Climara Pro
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Cholestyramine Light-Clinac BPO 7
- Cholestyramine Light-Clinacort
- Cholestyramine Light-Clinda-Derm
- Cholestyramine Light-Clinda-Derm Topical
- Climara Pro transdermal-Cholestyramine Resin
- Climara Pro transdermal-Choletec
- Climara Pro transdermal-Cholic acid
- Climara Pro transdermal-Choline magnesium trisalicylate
- Climara Pro transdermal-Choline Magnesium Trisalicylate Liquid
- Climara Pro transdermal-Cholografin Meglumine