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Cholestyramine Light and Coumadin

Determining the interaction of Cholestyramine Light and Coumadin and the possibility of their joint administration.

Check result:

Cholestyramine Light <> Coumadin

Relevance: 11.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cholestyramine together with warfarin can decrease the affects of warfarin. You should take warfarin at least one hour before or four to six hours after cholestyramine. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Contact your doctor if your experience any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Call your doctor promptly if you have any signs of blood clots such as chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity. It is important to tell your doctor about all other medications that you are using including vitamins and herbs. Do not stop using your medications without talking to your doctor first.

Professional:

MONITOR: Cholestyramine may decrease the absorption and increase the elimination of warfarin or other oral anticoagulants. Anticoagulant effect may be reduced. However, cholestyramine also may impair vitamin K absorption, and the anticoagulant effect of warfarin may be enhanced in some patients. Starting or stopping cholestyramine in the presence of chronic oral anticoagulant therapy may lead to altered PT or INR.

MANAGEMENT: Warfarin or other oral anticoagulants should be administered at least one hour before or four to six hours after cholestyramine. The INR or PT should be closely monitored. Patients should be advised to promptly report any signs of bleeding (e.g., pain, swelling, headache, dizziness, weakness, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools) or clots (e.g. chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity).

References

Longstreth GF, Newcomer AD "Drug-induced malabsorption." Mayo Clin Proc 50 (1975): 284-93
Wells PS, Holbrook AM, Crowther NR, Hirsh J "Interactions of warfarin with drugs and food." Ann Intern Med 121 (1994): 676-83
Koch-Weser J, Sellers EM "Drug interactions with coumarin anticoagulants (first of two parts)." N Engl J Med 285 (1971): 487-98
Robinson DS, Benjamin DM, McCormack JJ "Interaction of warfarin and nonsystemic gastrointestinal drugs." Clin Pharmacol Ther 12 (1971): 491-5
Gross L, Brotman M "Hypoprothrombinemia and hemorrhage associated with cholestyramine therapy." Ann Intern Med 72 (1970): 95-6
"Product Information. Questran (cholestyramine)." Par Pharmaceutical Inc, Chestnut Ridge, NY.
Ku LL, Ward CO, Durgin SJ "A clinical study of drug interaction and anticoagulant therapy." Drug Intell Clin Pharm 4 (1970): 300-6

Cholestyramine Light

Generic Name: cholestyramine

Brand name: Cholestyramine Light, Prevalite, Questran, Questran Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets

Synonyms: n.a.

What is Cholestyramine Light?

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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