Choline Magnesium Trisalicylate Liquid and Dilantin injection
Determining the interaction of Choline Magnesium Trisalicylate Liquid and Dilantin injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:In vitro studies suggest that salicylates may displace phenytoin from plasma protein-binding sites. The potential for phenytoin toxicity exists. The clinical significance is unknown. One case of phenytoin toxicity has been reported in a patient taking aspirin. However, clinical studies in healthy subjects and epileptic patients (taking phenytoin and 1500 mg aspirin/day) have not reported significant pharmacokinetic changes, adverse effects, or loss of seizure control.
- Neuvonen PJ, Lehtovaara R, Bardy A, Elomaa E "Antipyretic analgesics in patients on antiepileptic drug therapy." Eur J Clin Pharmacol 15 (1979): 263-8
- Fraser DG, Ludden TM, Evens RP, Sutherland EW "Displacement of phenytoin from plasma binding sites by salicylate." Clin Pharmacol Ther 27 (1980): 165-9
- Leonard RF, Knott PJ, Rankin GO, et al "Phenytoin-salicylate interaction." Clin Pharmacol Ther 29 (1981): 56-60
- Paxton JW "Effects of aspirin on salivary and serum phenytoin kinetics in healthy subjects." Clin Pharmacol Ther 27 (1980): 170-8
- Lunde PK, Rane A, Yaffe SJ, Lund L, Sjoqvist F "Plasma protein binding of diphenylhydantoin in man: interaction with other drugs and the effect of temperature and plasma dilution." Clin Pharmacol Ther 11 (1970): 846-55
Generic Name: choline salicylate / magnesium salicylate
Brand name: Choline magnesium trisalicylate, Tricosal, Trilisate, CMT
Synonyms: n.a.
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Dilantin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Choline Magnesium Trisalicylate Liquid-Dilantin Kapseals
- Choline Magnesium Trisalicylate Liquid-Dilantin-125
- Choline Magnesium Trisalicylate Liquid-Dilantin-30
- Choline Magnesium Trisalicylate Liquid-Dilatrate-SR
- Choline Magnesium Trisalicylate Liquid-Dilaudid
- Choline Magnesium Trisalicylate Liquid-Dilaudid (Hydromorphone Injection)
- Dilantin injection-Cholografin Meglumine
- Dilantin injection-Chondroitin
- Dilantin injection-Chondroitin and glucosamine
- Dilantin injection-Chondroitin, glucosamine, and methylsulfonylmethane MSM
- Dilantin injection-Chorex
- Dilantin injection-Choriogonadotropin Alfa