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Chromax and Tolazamide

Determining the interaction of Chromax and Tolazamide and the possibility of their joint administration.

Check result:

Chromax <> Tolazamide

Relevance: 20.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using chromium picolinate if you are diabetic. Depending on the dose and formulation, regular use of chromium picolinate may help control blood glucose levels in some patients, which may lead to a reduction in your dosage requirement of TOLAZamide or any other diabetic medications you are receiving. Your blood glucose should be closely monitored so that medications may be adjusted accordingly by your doctor. Let your doctor know if you experience hypoglycemia, or low blood sugar. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Pharmacologic dosages of chromium (200 mcg/day or more for adults) may help improve diabetic control and reduce the requirements for insulin and other antidiabetic agents. Chromium appears to play a role in normal insulin function and glucose utilization, and some investigators have suggested that it increases insulin sensitivity and glucose tolerance and decreases blood glucose levels in certain diabetics, possibly those with low chromium levels. However, others have not corroborated these findings, and a few have even reported a negative effect on glucose tolerance and blood levels.

MANAGEMENT: Until further data are available, therapy with pharmacologic dosages of chromium should be administered cautiously in patients receiving insulin or other antidiabetic agents. Patients should be monitored for changes in diabetic medication requirements.

References

Martin J, Wang ZQ, Zhang XH, et al. "Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes." Diabetes Care 29 (2006): 1826-32
Fox GN, Sabovic Z "Chromium picolinate supplementation for diabetes mellitus." J Fam Pract 46 (1998): 83-6
Mertz W "Interaction of chromium with insulin: a progress report." Nutr Rev 56 (1998): 174-7
Anderson RA, cheng N, Bryden NA, et al "Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes." Diabetes 46 (1997): 1786-91
Althuis MD, Jordan NE, Ludington EA, Wittes JT "Glucose and insulin responses to dietary chromium supplements: a meta-analysis." Am J Clin Nutr 76 (2002): 148-55
Bratman S, Kroll D. "The Natural Health Bible: From the Most Trusted Alternative Health Site in the World--Your A-Z Guide to over 300 Conditions, Herbs, Vitamins, and Supplements." Roseville, CA: Prima Health (2000):
Gunton JE, Cheung NW, Hitchman R, et al. "Chromium supplementation does not improve glucose tolerance, insulin sensitivity, or lipid profile: a randomized, placebo-controlled, double-blind trial of supplementation in subjects with impaired glucose tolerance." Diabetes Care 28 (2005): 712-3
Anderson RA "Chromium, glucose intolerance and diabetes." J Am Coll Nutr 17 (1998): 548-55
Abraham AS, Brooks BA, Eylath U "The effects of chromiium supplementation on serum glucose and lipids in patients with and without non-insulin-dependent diabetes." Metabolism 41 (1992): 768-71

Chromax

Generic Name: chromium picolinate

Brand name: Cr-GTF, CRM, Chromium GTF

Synonyms: Chromium picolinate, Chromium

What is Chromax?

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

What is Tolazamide?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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