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Cialis and Conivaptan Hydrochloride

Determining the interaction of Cialis and Conivaptan Hydrochloride and the possibility of their joint administration.

Check result:

Cialis <> Conivaptan Hydrochloride

Relevance: 13.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using tadalafil together with conivaptan. This combination may increase the adverse effects of tadalafil. This can cause chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting. Patients currently using tadalafil should consider not using tadalafil during administration of conivaptan. You should allow an appropriate amount of time following completion of conivaptan therapy before resuming tadalafil. Furthermore, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw during sexual activity, stop and call your doctor right away. You could be having a serious side effect. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with conivaptan may significantly increase the plasma concentrations of phosphodiesterase-5 (PDE5) inhibitors. The mechanism is conivaptan inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of these agents. Although the interaction has not been specifically studied, high plasma levels of PDE5 inhibitors (e.g., due to high doses or interaction with other potent 3A4 inhibitors such as protease inhibitors) have been associated with increased PDE5 adverse effects such as headache, flushing, dyspepsia, rhinitis, visual disturbances, hypotension, and even death. In pharmacokinetic studies with other drugs that are primarily metabolized by CYP450 3A4 such as midazolam, simvastatin, and amlodipine, conivaptan has increased systemic exposure (AUC) by 2- to 3-fold.

MANAGEMENT: Use of PDE5 inhibitors should preferably be avoided in patients treated with conivaptan. Patients currently using PDE5 inhibitors should consider an interruption during administration of conivaptan, and allow an appropriate amount of time following completion of conivaptan therapy before resuming these medications.

References

"Product Information. Vaprisol (conivaptan)." Cumberland Pharmaceuticals Inc, Nashville, TN.
Nandwani R, Gourlay Y "Possible interaction between sildenafil and HIV combination therapy." Lancet 353 (1999): 840
Merry C, Barry MG, Ryan M, Tjia JF, Hennessy M, Eagling VA, Mulcahy F, Back DJ "Interaction of sildenafil and indinavir when co-administered to HIV-positive patients." AIDS 13 (1999): f101-7
Warrington JS, Shader RI, vonMoltke LL, Greenblatt DJ "In vitro biotransformation of sildenafil (Viagra): Identification of human cytochromes and potential drug interactions." Drug Metab Disposition 28 (2000): 392-7
Hyland R, Roe GH, Jones BC, Smith DA "Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil." Br J Clin Pharmaacol 51 (2001): 239-48
Hall MCS, Ahmad S "Interaction between sildenafil and HIV-1 combination therapy." Lancet 353 (1999): 2071-2

Cialis

Generic Name: tadalafil

Brand name: Adcirca, Cialis, Alyq

Synonyms: n.a.

What is Cialis?

Conivaptan Hydrochloride

Generic Name: conivaptan

Brand name: Vaprisol

Synonyms: Conivaptan

What is Conivaptan Hydrochloride?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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