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Cidofovir and Entresto

Determining the interaction of Cidofovir and Entresto and the possibility of their joint administration.

Check result:

Cidofovir <> Entresto

Relevance: 17.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Cidofovir may increase the blood levels and effects of sacubitril. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with inhibitors of the hepatic uptake transporters OATP1B1, OATP1B3, OAT1, or OAT3 may increase systemic exposure to the active metabolite of sacubitril, LBQ657, which is a substrate of these transporters.

MANAGEMENT: Caution is advised if sacubitril is used in combination with inhibitors of OATP1B1, OATP1B3, OAT1, or OAT3. Pharmacologic response and blood pressure should be monitored more closely following the addition, discontinuation, or change of dosage of the transporter inhibitor, and the sacubitril dosage adjusted as necessary.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "Canadian Product Information." O 0 (2015):

Cidofovir

Generic Name: cidofovir

Brand name: Vistide

Synonyms: n.a.

What is Cidofovir?

Entresto

Generic Name: sacubitril / valsartan

Brand name: Entresto

Synonyms: n.a.

What is Entresto?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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