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Cimetidine and Dobutamine Injection

Determining the interaction of Cimetidine and Dobutamine Injection and the possibility of their joint administration.

Check result:
Cimetidine <> Dobutamine Injection
Relevance: 14.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using DOBUTamine together with cimetidine may increase the effects of DOBUTamine. Contact your doctor if you experience increased side effects or if your blood pressure increases. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Limited data suggest that dobutamine, when used in combination with cimetidine, may lead to increased pressor effects resulting in hypertension. The mechanism is unknown and causality has not been definitely established. It is not known if this reaction would occur with other H-2 antagonists.

MANAGEMENT: Monitor the patient's blood pressure more closely and adjust the dose of dobutamine if needed.

References
  • "Product Information. Methotrexate (methotrexate)." Lederle Laboratories, Wayne, NJ.
Cimetidine

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: n.a.

Dobutamine Injection

Generic Name: dobutamine

Brand name: Dobutrex

Synonyms: Dobutamine, DOBUTamine

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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