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Cimetidine and Hydroxyzine Injection

Determining the interaction of Cimetidine and Hydroxyzine Injection and the possibility of their joint administration.

Check result:

Cimetidine <> Hydroxyzine Injection

Relevance: 14.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Cimetidine has been shown to increase the serum concentration of hydroxyzine. The clinical significance of this interaction is not known. The mechanism may be cimetidine-induced inhibition of hydroxyzine metabolism. If cimetidine and hydroxyzine are coadministered, the patient should be monitored for excessive somnolence.

References

Simons FE, Sussman GL, Simons KJ "Effect of the H2-antagonist cimetidine on the pharmacokinetics and pharmacodynamics of the H1-antagonists hydroxyzine and cetirizine in patients with chronic urticaria." J Allergy Clin Immunol 95 (1995): 685-93

Cimetidine

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: n.a.

What is Cimetidine?

Hydroxyzine Injection

Generic Name: hydroxyzine

Brand name: ANX, Vistaril, Atarax, Vistaril IM, Hyzine, Vistaject-50, Rezine

Synonyms: Hydroxyzine, HydrOXYzine

What is Hydroxyzine Injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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