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Cimetidine and Lamisil Oral Granules

Determining the interaction of Cimetidine and Lamisil Oral Granules and the possibility of their joint administration.

Check result:

Cimetidine <> Lamisil Oral Granules

Relevance: 14.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Cimetidine reduces the clearance of terbinafine by 33%. The mechanism probably is inhibition of hepatic enzymes by cimetidine. This interaction is unlikely to be of clinical importance; however, the dosage of terbinafine should be adjusted as necessary.

References

"Product Information. Lamisil (terbinafine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Long CC, Hill SA, Thomas RC, Johnston A, Smith SG, Kendall F, Finlay AY "Effect of terbinafine on the pharmacokinetics of cyclosporin in humans." J Invest Dermatol 102 (1994): 740-3

Cimetidine

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: n.a.

What is Cimetidine?

Lamisil Oral Granules

Generic Name: terbinafine

Brand name: Lamisil, Terbinex

Synonyms: Lamisil

What is Lamisil Oral Granules?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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