Cimetidine and Orphenadrine, aspirin, and caffeine
Determining the interaction of Cimetidine and Orphenadrine, aspirin, and caffeine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Caffeine effects may be increased in patients also taking cimetidine. The mechanism may be due to decreased caffeine metabolism induced by cimetidine. Although adequate clinical data are lacking, a reduction in dose or elimination of caffeine may be needed if excess CNS stimulation is observed.
- "Product Information. Tagamet (cimetidine)." SmithKline Beecham, Philadelphia, PA.
- Broughton LJ, Rodgers HJ "Decreased systenuc clearance of caffeine due to cimetidine." Br J Clin Pharmacol 12 (1981): 155-9
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: n.a.
Generic Name: aspirin / caffeine / orphenadrine
Brand name: Norgesic Forte, Orphengesic Forte, Norgesic, Orphengesic
Synonyms: Aspirin, caffeine, and orphenadrine, Orphenadrine Aspirin Caffeine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cimetidine-Orphenate
- Cimetidine-Orphengesic
- Cimetidine-Orphengesic Forte
- Cimetidine-Orsythia
- Cimetidine-Ortho D
- Cimetidine-Ortho Evra
- Orphenadrine, aspirin, and caffeine-Cimetidine Hydrochloride
- Orphenadrine, aspirin, and caffeine-Cimetidine Injection
- Orphenadrine, aspirin, and caffeine-Cimetidine Oral Solution
- Orphenadrine, aspirin, and caffeine-Cimetidine Sodium Chloride
- Orphenadrine, aspirin, and caffeine-Cimetidine Tablets
- Orphenadrine, aspirin, and caffeine-Cimzia