Cimetidine and Propafenone

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using propafenone together with cimetidine may increase the effects of propafenone. Contact your doctor if you experience tiredness, dizziness, fainting, confusion, slow heart beats, seizures, and a worsening irregular heartbeat. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Cimetidine may inhibit the hepatic metabolism of propafenone. Increased plasma propafenone levels and a significantly increased QRS duration may result. The mechanism is inhibition of CYP450 2D6 metabolism by cimetidine.

MANAGEMENT: Patients receiving this combination should be monitored for altered efficacy and safety of propafenone. If plasma propafenone levels are high or toxicity is suspected, either cimetidine dosage or propafenone dosage should be decreased, or an alternative H2-antagonist (famotidine, nizatidine, ranitidine) should be considered. Patients should be advised to notify their physician if they experience nausea, vomiting, dizziness, blurry vision, palpitations, faster or slower heartbeat, or irregular heartbeat.

Cimetidine

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: n.a.

What is Cimetidine?

Propafenone

Generic Name: propafenone

Brand name: Rythmol, Rythmol SR

Synonyms: n.a.

What is Propafenone?