Cimetidine and Trental

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Cimetidine may increase the blood levels of pentoxifylline. In some cases, this may increase side effects such as dizziness, headache, nausea, vomiting, diarrhea, and abdominal pain or discomfort. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek prompt medical attention if you experience serious side effects such as bleeding, chest pain, or irregular heart rhythm. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with cimetidine may increase the plasma concentrations of pentoxifylline. The proposed mechanism is cimetidine inhibition of the CYP450 1A2-mediated metabolism of pentoxifylline. In 10 healthy study subjects given pentoxifylline controlled-release 400 mg every 8 hours, mean pentoxifylline systemic exposure (AUC) increased by approximately 26% and apparent oral clearance decreased by nearly 22% following the addition of cimetidine 300 mg four times daily for 7 days. Some adverse effects such as headache, nausea, and vomiting were reportedly increased during coadministration with cimetidine.

MANAGEMENT: Pharmacologic response to pentoxifylline should be monitored more closely whenever cimetidine is added to or withdrawn from therapy, and the pentoxifylline dosage adjusted as necessary. Patients should be advised to seek medical attention if they experience serious adverse effects such as bleeding, angina, or arrhythmias. Alternatively, agents that do not inhibit CYP450 1A2 such as famotidine, ranitidine, or proton pump inhibitors may be considered when acid suppression is required in patients receiving pentoxifylline.

Cimetidine

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: n.a.

What is Cimetidine?

Trental

Generic Name: pentoxifylline

Brand name: Trental, Pentoxil

Synonyms: n.a.

What is Trental?