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Cimetidine Injection and Clarithromycin Extended-Release Tablets

Determining the interaction of Cimetidine Injection and Clarithromycin Extended-Release Tablets and the possibility of their joint administration.

Check result:

Cimetidine Injection <> Clarithromycin Extended-Release Tablets

Relevance: 21.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration of cimetidine (800 mg dosed to steady state) and clarithromycin (500 mg as a single dose) prolonged the absorption of clarithromycin resulting in decreased peak plasma concentration of clarithromycin and its metabolite and significantly increased half lives. There were no changes in clearance or AUC. The mechanism and clinical significance of this interaction are unknown. Patients receiving this combination should be monitored for possible subtherapeutic effects of the antibiotic.

References

Amsden GW, Cheng KL, Peloquin CA, Nafziger AN "Oral cimetidine prolongs clarithromycin absorption." Antimicrob Agents Chemother 42 (1998): 1578-80

Cimetidine Injection

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Injection?

Clarithromycin Extended-Release Tablets

Generic Name: clarithromycin

Brand name: Biaxin, Biaxin XL

Synonyms: Clarithromycin

What is Clarithromycin Extended-Release Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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