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Cimetidine Injection and Equetro

Determining the interaction of Cimetidine Injection and Equetro and the possibility of their joint administration.

Check result:

Cimetidine Injection <> Equetro

Relevance: 21.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using carBAMazepine together with cimetidine may increase the effects of carBAMazepine. Contact your doctor if you experience shallow breathing, fast heartbeat, nausea, vomiting, urinating less or not at all, muscle twitches, restlessness, tremors, slurred speech, staggering walk, and feeling light-headed or fainting. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Cimetidine may increase carbamazepine levels by inhibiting its CYP450 3A4 hepatic metabolism. Carbamazepine toxicity is possible.

MANAGEMENT: If these drugs must be used together, close observation for clinical and laboratory evidence of carbamazepine toxicity is recommended. Patients should be advised to report possible symptoms of carbamazepine toxicity (nausea, visual disturbances, dizziness, or ataxia). Dose reductions may be required. Famotidine, nizatidine and ranitidine are not expected to inhibit hepatic metabolism and may be considered as alternatives.

References

Dalton MJ, Powell JR, Messenheimer JA Jr, Clark J "Cimetidine and carbamazepine: a complex drug interaction." Epilepsia 27 (1986): 553-8
Telerman-Toppet N, Duret ME, Coers C "Cimetidine interaction with carbamazepine." Ann Intern Med 94 (1981): 544

Cimetidine Injection

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Injection?

Equetro

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Equetro?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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