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Cimetidine Injection and Lignospan Forte

Determining the interaction of Cimetidine Injection and Lignospan Forte and the possibility of their joint administration.

Check result:

Cimetidine Injection <> Lignospan Forte

Relevance: 21.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using lidocaine together with cimetidine can increase the effects of lidocaine. You should notify your doctor if use lidocaine together with cimetidine. Contact your doctor if you experience tremor, lightheadedness, or an involuntary rapid, rhythmic movement of the eyeball. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Cimetidine may decrease the clearance of lidocaine. The proposed mechanism is inhibition of hepatic CYP450 metabolism and reduced hepatic blood flow. Serum lidocaine concentrations and risk of toxicity may be increased.

MANAGEMENT: Patients receiving concomitant therapy should be monitored for clinical (tremor, nystagmus, lightheadedness) and laboratory evidence of lidocaine toxicity. A reduction in the lidocaine infusion rate may be necessary. Nizatidine and famotidine are not expected to interact and may be considered as alternatives.

References

Jackson JE, Bentley JB, Glass SJ, et al "Effects of histamine-2 receptor blockade on lidocaine kinetics." Clin Pharmacol Ther 37 (1985): 544-8
Knapp AB, Maguire W, Keren G, et al. "The cimetidine-lidocaine interaction." Ann Intern Med 98 (1983): 174-7
Wing LM, Miners JO, Birkett DJ, et al "Lidocaine disposition: sex differences and effects of cimetidine." Clin Pharmacol Ther 35 (1984): 695-701
Feely J, Wilkinson GR, McAllister CB, Wood AJ "Increased toxicity and reduced clearance of lidocaine by cimetidine." Ann Intern Med 96 (1982): 592-4
Powell JR, Foster J, Patterson JH, Cross R, Wargin W "Effect of duration of lidocaine infusion and route of cimetidine administration on lidocaine pharmacokinetics." Clin Pharm 5 (1986): 993-8
Berk SI, Gal P, Bauman JL, et al "The effect of oral cimetidine on total and unbound serum lidocaine concentrations in patients with suspected myocardial infarction." Int J Cardiol 14 (1987): 91-4
Robson RA, Wing LMH, Miners JO, Lillywhite KJ, Birkett DJ "The effect of ranitidine on the disposition of lignocaine." Br J Clin Pharmacol 20 (1985): 170-3

Cimetidine Injection

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Injection?

Lignospan Forte

Generic Name: epinephrine / lidocaine

Brand name: D-Care 100X, Lignospan Forte, Lignospan Standard, Xylocaine MPF With Epinephrine, Xylocaine With Epinephrine

Synonyms: Lignospan Forte Injection

What is Lignospan Forte?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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