Cimetidine Oral Solution and Colchicine
Determining the interaction of Cimetidine Oral Solution and Colchicine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using colchicine together with cimetidine may increase the effects of colchicine. Contact your doctor if you experience diarrhea, nausea, vomiting, fever, muscle aches or weakness, abdominal pain, or seizures. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of cimetidine has resulted in decreased colchicine clearance in animal studies. The mechanism may be inhibition of microsomal enzymes by cimetidine. Increased colchicine levels may result in toxicity such as myoneuropathy, multiple organ failure, or death. No interaction has been reported in humans. Patients with any level of renal or hepatic impairment may have a higher risk of developing toxicity.
MANAGEMENT: Patients receiving this combination should be monitored for toxicity and serum colchicine levels should be checked. Patients should be advised to notify their physician if they experience diarrhea, nausea, vomiting, fever, muscle aches or weakness, abdominal pain, or seizures.
- "Product Information. Colchicine (colchicine)." Lilly, Eli and Company, Indianapolis, IN.
- Leighton JA, Bay MK, Maldonado AL, et al "The effect of liver dysfunction on colchicine pharmacokinetics in the rat." Hepatology 11 (1990): 210-5
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: Cimetidine
Generic Name: colchicine
Brand name: Colcrys, Mitigare
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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