Cimetidine Oral Solution and Dalfampridine
Determining the interaction of Cimetidine Oral Solution and Dalfampridine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Cimetidine may increase the blood levels and effects of dalfampridine. You may be more likely to experience side effects of dalfampridine such as nausea, insomnia, dizziness, weakness, headache, confusion, and seizures. Contact your doctor if you have increased side effects or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Theoretically, the concomitant use of dalfampridine with drugs that are inhibitors of organic cation transporter 2 (OCT2) may significantly reduce its renal clearance. Dalfampridine is primarily eliminated through renal excretion; approximately 60% of it via active secretion by OCT2 (in vitro). The risk of CNS excitation and seizures may be increased.
MANAGEMENT: Caution is recommended during concomitant use. European product labeling considers concomitant use contraindicated.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: Cimetidine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cimetidine Oral Solution-Dalfopristin and quinupristin
- Cimetidine Oral Solution-Daliresp
- Cimetidine Oral Solution-Dallergy
- Cimetidine Oral Solution-Dallergy (Dexbrompheniramine and Phenylephrine Syrup)
- Cimetidine Oral Solution-Dallergy (Dexbrompheniramine and Phenylephrine Tablets)
- Cimetidine Oral Solution-Dallergy Chewable Tablets
- Dalfampridine-Cimetidine Sodium Chloride
- Dalfampridine-Cimetidine Tablets
- Dalfampridine-Cimzia
- Dalfampridine-Cimzia (Certolizumab Prefilled Syringes)
- Dalfampridine-Cimzia (Certolizumab Vials)
- Dalfampridine-Cinacalcet