Cimetidine Oral Solution and Demerol

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using meperidine together with cimetidine can increase the blood levels or add to the side effects of meperidine. Call the doctor if you have side effects such as extreme drowsiness, muscle weakness, confusion, cold and clammy skin, pinpoint pupils, shallow breathing, slow heart rate, or fainting. You should avoid activities requiring mental alertness until they know how these agents affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with cimetidine may increase the plasma concentrations of meperidine. The proposed mechanism is cimetidine inhibition of meperidine metabolism via hepatic microsomal enzymes. In eight young, healthy volunteers, cimetidine (1200 mg orally per day for 7 days) decreased total body clearance and volume of distribution of meperidine (70 mg single intravenous dose) by 22% and 13%, respectively, compared to administration of meperidine alone. The peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of the pharmacologically active metabolite, normeperidine, was reduced by 29% and 23%, respectively. In another study, ranitidine (150 mg twice a day) was found to have no significant effect on the pharmacokinetics of meperidine in eight healthy volunteers.

MANAGEMENT: Caution is advised if meperidine must be used with cimetidine. Patients should be closely monitored for potentially excessive or prolonged central nervous system and respiratory depression. Ambulatory patients should be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, confusion) and counseled to avoid activities requiring mental alertness until they know how these agents affect them. Patients should also be advised to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities. Alternatively, use of another H2-antagonist such as famotidine, nizatidine, or ranitidine may be considered, as these agents have not been shown to significantly affect CYP450 metabolism.

Cimetidine Oral Solution

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Oral Solution?

Demerol

Generic Name: meperidine

Brand name: Demerol, Demerol HCl, Meperitab

Synonyms: n.a.

What is Demerol?