Cimetidine Oral Solution and Divalproex sodium
Determining the interaction of Cimetidine Oral Solution and Divalproex sodium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Cimetidine may inhibit the hepatic metabolism of valproate. Reductions in valproate clearance of 2% to 17% have been reported. The clinical significance of this interaction is unknown. The interaction may be most significant in patients with serum valproic acid levels near the upper limit of the therapeutic range.
- Webster LK, Mihaly GW, Jones DB, et al "Effect of cimetidine and ranitidine on carbamazepine and sodium valproate pharmacokinetics." Eur J Clin Pharmacol 27 (1984): 341-3
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: Cimetidine
Generic Name: divalproex sodium
Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon
Synonyms: Divalproex
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cimetidine Oral Solution-Divalproex Sprinkle
- Cimetidine Oral Solution-Divalproex Sprinkle Capsules
- Cimetidine Oral Solution-Divigel
- Cimetidine Oral Solution-Divigel 0.75 mg/packet for use on skin
- Cimetidine Oral Solution-Divigel Transdermal
- Cimetidine Oral Solution-Divista
- Divalproex sodium-Cimetidine Sodium Chloride
- Divalproex sodium-Cimetidine Tablets
- Divalproex sodium-Cimzia
- Divalproex sodium-Cimzia (Certolizumab Prefilled Syringes)
- Divalproex sodium-Cimzia (Certolizumab Vials)
- Divalproex sodium-Cinacalcet