Cimetidine Oral Solution and Excedrin Mild Headache
Determining the interaction of Cimetidine Oral Solution and Excedrin Mild Headache and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Animal studies and some limited human studies have suggested that cimetidine may decrease the potential hepatotoxic effects of acetaminophen. The mechanism may be related to reductions in the rate at which reactive intermediate metabolites are formed. Not all studies have confirmed the occurrence of this interaction. No alterations in dosage are necessary.
- Slattery JT, McRorie TI, Reynolds R, et al "Lack of effect of cimetidine on acetaminophen disposition in humans." Clin Pharmacol Ther 46 (1989): 591-7
- Dalhoff K, Poulsen HE "Inhibition of acetaminophen oxidation by cimetidine and the effects on glutathione and activated sulphate synthesis rates." Pharmacol Toxicol 73 (1993): 215-8
- Mitchell MC, Schenker S, Speeg KV "Selective inhibition of acetaminophen oxidation and toxicity by cimetidine and other histamine H2-receptor antagonists in vivo and in vitro in the rat and in man." J Clin Invest 73 (1984): 383-91
- Vendemiale G, Altomare E, Trizio T, Leandro G, Manghisi OG, Albano O "Effect of acute and chronic cimetidine administration on acetaminophen metabolism in humans." Am J Gastroenterol 82 (1987): 1031-4
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: Cimetidine
Generic Name: acetaminophen / caffeine
Brand name: Excedrin Mild Headache, Excedrin Quick Tab Peppermint, Excedrin Quick Tab Spearmint, Excedrin Tension Headache, Excedrin Tension Headache Caplet, Excedrin Tension Headache Express Gels, Excedrin Tension Headache Geltab, Valorin Extra, Excedrin Tension Headache Express
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cimetidine Oral Solution-Excedrin PM
- Cimetidine Oral Solution-Excedrin Quick Tab Peppermint
- Cimetidine Oral Solution-Excedrin Quick Tab Spearmint
- Cimetidine Oral Solution-Excedrin Sinus Headache Caplet
- Cimetidine Oral Solution-Excedrin Tension Headache
- Cimetidine Oral Solution-Excedrin Tension Headache Caplet
- Excedrin Mild Headache-Cimetidine Sodium Chloride
- Excedrin Mild Headache-Cimetidine Tablets
- Excedrin Mild Headache-Cimzia
- Excedrin Mild Headache-Cimzia (Certolizumab Prefilled Syringes)
- Excedrin Mild Headache-Cimzia (Certolizumab Vials)
- Excedrin Mild Headache-Cinacalcet