Cimetidine Oral Solution and Hexalen

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using cimetidine together with altretamine. Using these medications together may increase the effects of altretamine. This can cause serious side effects including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; fever or chills; or signs of infection such as fever; chills, or sore throat); neurologic problems (mood disorders, altered consciousness, weakness, dizziness, vertigo); and others. Contact your doctor if you condition worsens. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: According to a rat model, the coadministration with cimetidine may increase the half-life and toxicity of altretamine. The likely mechanism is cimetidine inhibition of altretamine metabolism via CYP450 isoenzymes. In the study, 20 to 120 mg/kg of cimetidine (up to 114% of recommended human dose based on BSA) increased in a dose-related manner the half-life of altretamine by 29% to 80%. Cimetidine 120 mg/kg increased the toxicity of a single 350 mg/kg dose of altretamine from LD30 to LD75. In contrast, ranitidine had no significant effect on half-life or toxicity of altretamine.

MANAGEMENT: Based on animal data as well as human case reports of increased toxicity when other antineoplastic agents have been administered with cimetidine, the concomitant use of altretamine and cimetidine should generally be avoided if possible. Ranitidine may be a safer alternative if H2-antagonist therapy is necessary. Famotidine and nizatidine may also be considered, since they have not been shown to interfere with CYP450 metabolism.

Cimetidine Oral Solution

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Oral Solution?

Hexalen

Generic Name: altretamine

Brand name: Hexalen

Synonyms: n.a.

What is Hexalen?