Cimetidine Oral Solution and Lamivudine and zidovudine
Determining the interaction of Cimetidine Oral Solution and Lamivudine and zidovudine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Cimetidine has been shown to significantly decrease (by 56%) the renal clearance of zidovudine, most likely by competition for active tubular secretion. However, serum levels of zidovudine and its primary metabolite were not affected. Since zidovudine is mostly metabolized by the liver this interaction is unlikely to be of clinical significance except in patients with hepatic impairment.
- Fletcher CV, Henry WK, Noormohamed SE, Rhame FS, Balfour HH "The effect of cimetidine and ranitidine administration with zidovudine." Pharmacotherapy 15 (1995): 701-8
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: Cimetidine
Generic Name: lamivudine / zidovudine
Brand name: Combivir
Synonyms: Lamivudine and Zidovudine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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