Cimetidine Oral Solution and Nicotrol Inhalation, oral/nebulization
Determining the interaction of Cimetidine Oral Solution and Nicotrol Inhalation, oral/nebulization and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:H2 antagonists may reduce the clearance of nicotine. Cimetidine, 600 mg given twice a day for two days, reduced clearance of an intravenous nicotine dose by 30%. Ranitidine, 300 mg given twice a day for two days, reduced clearance by 10%. The clinical significance of this interaction is not known. Patients should be monitored for increased nicotine effects when using the patches or gum for smoking cessation and dosage adjustments should be made as appropriate.
- Bendayan R, Sullivan JT, Shaw C, Frecker RC, Sellers EM "Effect of cimetidine and ranitidine on the hepatic and renal elimination of nicotine in humans." Eur J Clin Pharmacol 38 (1990): 165-9
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: Cimetidine
Generic Name: nicotine
Brand name: Nicotrol Inhaler, Nicotrol NS, Commit, Leader Nicotine Polacrilex, Nicorelief, Nicorette, Thrive, Habitrol, Nicoderm C-Q, Nicotine System Kit, Nicoderm CQ
Synonyms: Nicotrol Inhaler (nasal, inhalation), Nicotrol Inhalant
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cimetidine Oral Solution-Nicotrol Inhaler
- Cimetidine Oral Solution-Nicotrol Inhaler nasal, inhalation
- Cimetidine Oral Solution-Nicotrol NS
- Cimetidine Oral Solution-Nicotrol NS nasal, inhalation
- Cimetidine Oral Solution-Nicotrol Oral, Transdermal
- Cimetidine Oral Solution-Nidagel
- Nicotrol Inhalation, oral/nebulization-Cimetidine Sodium Chloride
- Nicotrol Inhalation, oral/nebulization-Cimetidine Tablets
- Nicotrol Inhalation, oral/nebulization-Cimzia
- Nicotrol Inhalation, oral/nebulization-Cimzia (Certolizumab Prefilled Syringes)
- Nicotrol Inhalation, oral/nebulization-Cimzia (Certolizumab Vials)
- Nicotrol Inhalation, oral/nebulization-Cinacalcet