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Cimetidine Oral Solution and Pentobarbital Sodium Injection

Determining the interaction of Cimetidine Oral Solution and Pentobarbital Sodium Injection and the possibility of their joint administration.

Check result:
Cimetidine Oral Solution <> Pentobarbital Sodium Injection
Relevance: 13.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Barbiturates may slightly reduce the bioavailability of cimetidine. Phenobarbital is the only barbiturate specifically implicated in this interaction. However, other barbiturates may behave in a similar fashion.

References
  • Somogyi A, Thielscher S, Gugler R "Influence of phenobarbital treatment on cimetidine kinetics." Eur J Clin Pharmacol 19 (1981): 343-7
Cimetidine Oral Solution

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

Pentobarbital Sodium Injection

Generic Name: pentobarbital

Brand name: Nembutal Sodium, Nembutal

Synonyms: Pentobarbital (injection), PENTobarbital

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.