Cimetidine Oral Solution and Pramipexole ER Tablets
Determining the interaction of Cimetidine Oral Solution and Pramipexole ER Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using pramipexole together with cimetidine may increase the effects of pramipexole. Contact your doctor if you experience extreme drowsiness, falling asleep suddenly, even after feeling alert. Sweating, fast or uneven heartbeats, or dizziness or feeling like you might pass out, especially when getting up from a sitting or lying position. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Cimetidine has been shown to cause a 50% increase in the pramipexole area under the concentration-time curve and a 40% increase in its half-life by inhibiting renal tubular secretion of pramipexole. Monitoring patients for altered efficacy and safety is recommended.
MANAGEMENT: Patients should be advised to notify their physician if they experience excessive drowsiness, somnolence, or orthostasis.
- "Product Information. Mirapex (pramipexole)." Boehringer Ingelheim, Ridgefield, CT.
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: Cimetidine
Generic Name: pramipexole
Brand name: Mirapex, Mirapex ER
Synonyms: Pramipexole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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