Drug search by name

Cimetidine Oral Solution and Pronestyl

Determining the interaction of Cimetidine Oral Solution and Pronestyl and the possibility of their joint administration.

Check result:

Cimetidine Oral Solution <> Pronestyl

Relevance: 13.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using procainamide together with cimetidine can increase the effects of procainamide. Contact your doctor if you experience drowsiness, dizziness, faint, confusion, tremor, or palpitations. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Cimetidine may increase plasma concentrations of procainamide and its active metabolite, NAPA. The mechanism is related to decreased renal tubular secretion of procainamide and NAPA. Increased procainamide serum concentrations may result in ECG changes such as QRS widening or prolonged QT interval and increased risk of arrhythmias such as torsades de pointes.

MANAGEMENT: If these two drugs are given together, serum procainamide and NAPA levels, ECG changes, and hemodynamic status should be closely monitored. Patients should be advised to promptly notify their physician if they experience drowsiness, dizziness, syncope, confusion, tremor, or palpitations. Famotidine and nizatidine do not appear to interact in this manner and may be considered as alternatives.

References

Lai MY, Jiang FM, Chung CH, et al "Dose dependent effect of cimetidine on procainamide disposition in man." Int J Clin Pharmacol Ther Toxicol 26 (1988): 118-21
Rodvold KA, Paloucek FP, Jung D, Gallastegui J "Interaction of steady-state procainamide with H2-receptor antagonists cimetidine and ranitidine." Ther Drug Monit 9 (1987): 378-83
Christian CD, Meredith CG, Speeg KV "Cimetidine inhibits renal procainamide clearance." Clin Pharmacol Ther 36 (1984): 221-7
Bauer LA, Black D, Gensler A "Procainamide-cimetidine drug interaction in elderly male patients." J Am Geriatr Soc 38 (1990): 467-9
Somogyi A, McLean A, Heinzow B "Cimetidine-procainamide pharmacokinetic interaction in man: evidence of competition for tubular secretion of basic drugs." Eur J Clin Pharmacol 25 (1983): 339-45
Higbee MD, Wood JS, Mead RA "Procainamide-cimetidine interaction: a potential toxic interaction in the elderly." J Am Geriatr Soc 32 (1984): 162-4

Cimetidine Oral Solution

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Oral Solution?

Pronestyl

Generic Name: procainamide

Brand name: Pronestyl, Procan SR, Pronestyl-SR, Procanbid

Synonyms: Pronestyl (injection)

What is Pronestyl?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions