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Cimetidine Oral Solution and Stuart One

Determining the interaction of Cimetidine Oral Solution and Stuart One and the possibility of their joint administration.

Check result:

Cimetidine Oral Solution <> Stuart One

Relevance: 13.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited data have suggested that concurrent administration of cimetidine may reduce the bioavailability of orally administered iron. In one study, dose-related reductions in the absorption of iron occurred following single oral doses of cimetidine (300 mg to 900 mg) compared to baseline. There has also been a case report of persistent inadequate response to iron therapy for the treatment of anemia during concomitant use of cimetidine 1 gm and ferrous sulfate 600 mg daily. Hematologic improvement was noted within a month after reducing the cimetidine dosage to 400 mg daily. Some investigators have suggested that cimetidine-induced increases in gastric pH may reduce the solubility of iron salts, which leads to decreased absorption. However, a study in patients with iron deficiency or iron-deficiency anemia found that response to iron therapy (iron succinyl-protein complex 2400 mg twice daily) was not affected by H2-receptor antagonists such as famotidine, nizatidine, or ranitidine. In another study, stable serum iron concentrations were observed in 64 patients receiving chronic therapy with cimetidine 400 mg to 800 mg/day. Based on existing evidence, no intervention (e.g., separating times of administration) appears to be necessary during concomitant use of cimetidine and iron products unless an interaction is suspected.

References

Bianchi FM, Cavassini GB, Leo P "Iron protein succynilate in the treatment of iron deficiency: potential interaction with H2-receptor antagonists." Int J Clin Pharmacol Ther Toxicol 31 (1993): 209-17
"Product Information. Tagamet (cimetidine)." SmithKline Beecham, Philadelphia, PA.
Rosner F "Cimetidine and iron absorption." Lancet 1 (1978): 95
Partlow ES, Campbell NRC, Chan SC, Pap KM, Granberg K, Hasinoff BB "Ferrous sulfate does not reduce serum levels of famotidine or cimetidine after concurrent ingestion." Clin Pharmacol Ther 59 (1996): 389-93

Cimetidine Oral Solution

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Oral Solution?

Stuart One

Generic Name: multivitamin, prenatal

Brand name: NataChew, Select-OB, A-Free Prenatal, Azesco, CitraNatal 90 DHA, CitraNatal Assure, CitraNatal B-Calm, Materna, Pramilet FA, Stuartnatal Plus, Natalins Rx, Norlac RX, Neo-Forte, Mynatal, Zenate Advanced Formula, Prenatal MR 90, O-Cal-FA, Equi-Natal Plus, Pan OB Forte, Hi-Nate 90, Lactocal-F, Maternity-90, Prenazyme 1+1, Pre-H-Cal, Femnatal, Vynatal 1 Plus 1, Par-F, Maternity, Niferex PN Forte, Prenavite, Mynatal PN, Obnate 90, Maternal 90, Mynatal Rx, PreCare, Natarex, Ternamar, Aminatal Plus, Elemental Iron-90, Mynatal PN Forte, Mynatal FC, Mynate 90 Plus, Vitamed Prenatal Formula, Zitamin, Preterna, Vernate, Vernate Advanced, Prenate 90, Aminate, Mission Prenatal Rx, Niferex-PN, Marnatal-F, Prenate Ultra, Prenatal Z Advanced Formula, Prenatal Plus, Zenate Prenatal, NatalCare, Prenatal Plus with Beta-Carotene, Prenatal Rx, Maternity plus Beta Carotene, Equi-Natal M, Equi-Natal Rx, Equinatal 90, Equi-Natal Z, Natalcare Pic Forte, Natalcare Pic, Natalins, Stuart Prenatal with Beta Carotene, Prenatal MR 90 Fe, Aminatal Plus One, Aminate with 90 mg Iron, Ultra NatalCare, Prenatal S, Natafort, Nestabs, Nestabs CBF, Vitafol PN, Fem-Natal, Ami-Natal Plus One Improved, Aminatal Plus New Formula, Prenatal Plus with 27 mg Iron, Obegyn, Mission Prenatal, Mission Prenatal FA, Mission Prenatal HP, Mynatal Z, Mynatal Plus, Mynatal Ultracap, Prenatal Plus Iron, Prenatal 1 Plus 1, Natalcare Plus, Prenatal MTR with Selenium, Natalcare Rx, Prenavite FC, Prenavite PC, Chromagen OB, Natatab CFe, Natatab FA, Vitelle Nestabs OTC, NataChew, Premesis Rx, Prenate Advanced Formula, Precare Conceive, Citracal Prenatal Rx, Advanced NatalCare, NutriNate, Nestabs Rx, Stuartnatal Plus 3, Strongstart, Anemagen OB, Ultra-Natal, NatalCare Three, Natatab Rx, Equi-Natal Care, Inatal Advance, Inatal Ultra, Maternity Vitamin Low Iron, Ob-20, Prenatabs CBF, Prenatal Rx Low Iron, Vinate 90, Vinate M, Vinate Ultra, Prenate GT, Ferrex PC Forte, Trinate, Prenatal AD, Prenatal 19, Natalcare, Prenatal H, Duet Chewable, Natalfirst, Natelle, Cenogen Ultra, Prenatal-U, Nestabs FA, Vinate GT, Natafolic-PN, Cal-Nate, Icar Prenatal, Prenate Advance, Novastart, Novanatal, Natacaps, O-Cal Prenatal, NatalCare Advanced-RF, Duet DHA, Prenatabs OBN, Icare Prenatal Rx, Vinatal 600, Nutrispire, PrimaCare One, PrenaFirst, Natafolic-OB, , Choice-OB+DHA, Select-OB+DHA, Stuart One

Synonyms: Prenatal Vitamin Chewable Tablet

What is Stuart One?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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