Cimetidine Oral Solution and Vfend

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with cimetidine may slightly increase the plasma concentrations of voriconazole. In 12 healthy male subjects, cimetidine (400 mg every 12 hours for 8 days) increased the steady-state peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of voriconazole (200 mg orally every 12 hours for 7 days) by an average of 18% and 23%, respectively, compared to placebo. Cimetidine had no effect on the half-life of voriconazole. In addition, adverse events were similar during coadministration with cimetidine or placebo. No particular action or caution is required, as this interaction is unlikely to be of clinical significance.

Cimetidine Oral Solution

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Oral Solution?

Vfend

Generic Name: voriconazole

Brand name: Vfend, Vfend

Synonyms: Vfend Injection

What is Vfend?