Cimetidine Oral Solution and Zomig-ZMT

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using ZOLMitriptan together with cimetidine may increase the effects of ZOLMitriptan. Contact your doctor if you experience drowsiness, dizziness, tingling or numbness of the skin, chest pain or tightness, shortness of breath, or irregular heartbeats. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Following the administration of cimetidine, the half-life and AUC of zolmitriptan and the active metabolite were increased by two-fold. The proposed mechanism is inhibition of CYP450 1A2 isoenzymes by cimetidine. Due to limited data, the clinical consequences of this interaction are unknown.

MANAGEMENT: It is recommended that not more than 5 mg of zolmitriptan should be taken in 24 hours during concomitant use of cimetidine. Patients should be advised to notify their doctor promptly if they experience sedation, dizziness, paresthesia, chest pain or tightness, shortness of breath, or irregular heartbeats.

Cimetidine Oral Solution

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Oral Solution?

Zomig-ZMT

Generic Name: zolmitriptan

Brand name: Zomig, Zomig-ZMT

Synonyms: n.a.

What is Zomig-ZMT?