Cimetidine Sodium Chloride and Ferrous Fumarate and Polysaccharide Iron Complex
Determining the interaction of Cimetidine Sodium Chloride and Ferrous Fumarate and Polysaccharide Iron Complex and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data have suggested that concurrent administration of cimetidine may reduce the bioavailability of orally administered iron. In one study, dose-related reductions in the absorption of iron occurred following single oral doses of cimetidine (300 mg to 900 mg) compared to baseline. There has also been a case report of persistent inadequate response to iron therapy for the treatment of anemia during concomitant use of cimetidine 1 gm and ferrous sulfate 600 mg daily. Hematologic improvement was noted within a month after reducing the cimetidine dosage to 400 mg daily. Some investigators have suggested that cimetidine-induced increases in gastric pH may reduce the solubility of iron salts, which leads to decreased absorption. However, a study in patients with iron deficiency or iron-deficiency anemia found that response to iron therapy (iron succinyl-protein complex 2400 mg twice daily) was not affected by H2-receptor antagonists such as famotidine, nizatidine, or ranitidine. In another study, stable serum iron concentrations were observed in 64 patients receiving chronic therapy with cimetidine 400 mg to 800 mg/day. Based on existing evidence, no intervention (e.g., separating times of administration) appears to be necessary during concomitant use of cimetidine and iron products unless an interaction is suspected.
- Bianchi FM, Cavassini GB, Leo P "Iron protein succynilate in the treatment of iron deficiency: potential interaction with H2-receptor antagonists." Int J Clin Pharmacol Ther Toxicol 31 (1993): 209-17
- "Product Information. Tagamet (cimetidine)." SmithKline Beecham, Philadelphia, PA.
- Rosner F "Cimetidine and iron absorption." Lancet 1 (1978): 95
- Partlow ES, Campbell NRC, Chan SC, Pap KM, Granberg K, Hasinoff BB "Ferrous sulfate does not reduce serum levels of famotidine or cimetidine after concurrent ingestion." Clin Pharmacol Ther 59 (1996): 389-93
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: Cimetidine
Generic Name: ferrous fumarate / iron polysaccharide
Brand name: Tandem
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cimetidine Sodium Chloride-Ferrous Fumarate Controlled-Release Tablets
- Cimetidine Sodium Chloride-Ferrous Fumarate Tablets and Capsules
- Cimetidine Sodium Chloride-Ferrous Fumarate, Polysaccharide Iron Complex, Vitamin C, and Vitamin B3
- Cimetidine Sodium Chloride-Ferrous gluconate
- Cimetidine Sodium Chloride-Ferrous Sulfate
- Cimetidine Sodium Chloride-Ferrous Sulfate Capsules and Tablets
- Ferrous Fumarate and Polysaccharide Iron Complex-Cimetidine Tablets
- Ferrous Fumarate and Polysaccharide Iron Complex-Cimzia
- Ferrous Fumarate and Polysaccharide Iron Complex-Cimzia (Certolizumab Prefilled Syringes)
- Ferrous Fumarate and Polysaccharide Iron Complex-Cimzia (Certolizumab Vials)
- Ferrous Fumarate and Polysaccharide Iron Complex-Cinacalcet
- Ferrous Fumarate and Polysaccharide Iron Complex-Cinacalcet Hydrochloride