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Cimetidine Sodium Chloride and Neoral

Determining the interaction of Cimetidine Sodium Chloride and Neoral and the possibility of their joint administration.

Check result:

Cimetidine Sodium Chloride <> Neoral

Relevance: 22.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Cimetidine has been reported to increase serum creatinine in patients treated with cyclosporine. However, the same effect has also been observed in patients not receiving cyclosporine, and investigators believe that cimetidine actually inhibits creatinine clearance by competing for renal tubular secretion. In general, studies have not demonstrated an adverse effect of cimetidine on renal function (as measured by inulin clearance and blood urea nitrogen) nor a significant effect on the pharmacokinetics of cyclosporine. However, in vitro data indicates that cimetidine may antagonize cyclosporine-induced inhibition of interleukin-2 production, which, theoretically, may result in diminished immunosuppressive activity of cyclosporine. A case report also describes a renal transplant patient who developed significantly increased blood cyclosporine concentrations during treatment with cimetidine and metronidazole, although it was uncertain whether one or a combination of both drugs caused the interaction. Current data do not support a pharmacokinetic or pharmacodynamic interaction with ranitidine, thus it may be preferable to cimetidine in patients treated with cyclosporine. No data are available for other H2-antagonists regarding coadministration with cyclosporine.

References

Gifford RR, Tilberg AF "Cimetidine reduces cyclosporine inhibition of interleukin-2 production." J Surg Res 45 (1988): 276-80
Jarowenko MV, Van Buren CT, Kramer WG, et al "Ranitidine, cimetidine, and the cyclosporine-treated recipient." Transplantation 43 (1986): 311-2
Pachon J, Lorber MI, Bia MJ "Effects of H2-receptor antagonists on renal function in cyclosporine-treated renal transplant patients." Transplantation 47 (1989): 254-9
D'Souza MJ, Pollock SH, Solomon HM "Cyclosporine-cimetidine interaction." Drug Metab Dispos 16 (1988): 57-9
Zylber-Katz E, Rubinger D, Berlatzky Y "Cyclosporine interactions with metronidazole and cimetidine." Drug Intell Clin Pharm 22 (1988): 504-5
Knodell RG, Browne DG, Gwozdz GP, et al "Differential inhibition of individual human liver cytochromes P-450 by cimetidine." Gastroenterology 101 (1991): 1680-91
Puff MR, Carey WD "The effect of cimetidine on cyclosporine A levels in liver transplant recipients: a preliminary report." Am J Gastroenterol 87 (1992): 287-91
Lewis SM, McClosky WW "Potentiation of nephrotoxicity by H2-antagonists in patients receiving cyclosporin." Ann Pharmacother 31 (1997): 363-5

Cimetidine Sodium Chloride

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Sodium Chloride?

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

What is Neoral?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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