Cimetidine Sodium Chloride and Tambocor
Determining the interaction of Cimetidine Sodium Chloride and Tambocor and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using flecainide together with cimetidine may increase the effects of flecainide. Contact your doctor if you experience tiredness, dizziness, confusion, difficulty breathing, heart attack, and a worsening irregular heartbeat. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Cimetidine may decrease the hepatic biotransformation or increase the bioavailability of flecainide. The time during which maximum plasma flecainide concentrations occur may be prolonged. No special precautions appear to be necessary in patients with normal renal function.
MANAGEMENT: Clinical monitoring for altered response and dosage reductions may be required in patients with renal impairment. Famotidine, nizatidine and ranitidine are not expected to interact and may be considered as alternatives.
- Tjandra-Maga TB, Van Hecken A, Van Melle P, Verbesselt R, de Schepper PJ "Altered pharmacokinetics of oral flecainide by cimetidine." Br J Clin Pharmacol 22 (1986): 108-10
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: Cimetidine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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