Cimetidine Tablets and Colchicine Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using colchicine together with cimetidine may increase the effects of colchicine. Contact your doctor if you experience diarrhea, nausea, vomiting, fever, muscle aches or weakness, abdominal pain, or seizures. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of cimetidine has resulted in decreased colchicine clearance in animal studies. The mechanism may be inhibition of microsomal enzymes by cimetidine. Increased colchicine levels may result in toxicity such as myoneuropathy, multiple organ failure, or death. No interaction has been reported in humans. Patients with any level of renal or hepatic impairment may have a higher risk of developing toxicity.

MANAGEMENT: Patients receiving this combination should be monitored for toxicity and serum colchicine levels should be checked. Patients should be advised to notify their physician if they experience diarrhea, nausea, vomiting, fever, muscle aches or weakness, abdominal pain, or seizures.

Cimetidine Tablets

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Tablets?

Colchicine Tablets

Generic Name: colchicine

Brand name: Colcrys, Mitigare

Synonyms: Colchicine

What is Colchicine Tablets?