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Cimetidine Tablets and Flagyl 375

Determining the interaction of Cimetidine Tablets and Flagyl 375 and the possibility of their joint administration.

Check result:

Cimetidine Tablets <> Flagyl 375

Relevance: 15.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration with cimetidine may increase the serum concentrations of nitroimidazoles. The interaction has been reported with metronidazole. In six healthy volunteers, the half-life of a single 400 mg intravenous dose of metronidazole increased from 6.2 to 7.9 hours following six days of cimetidine administration. The plasma clearance was reduced 30%. The proposed mechanism is cimetidine inhibition of the hepatic metabolism of metronidazole. No data are available for tinidazole. This interaction is unlikely to be of clinical significance.

References

"Product Information. Tindamax (tinidazole)." Presutti Laboratories Inc, Arlington Heights, IL.
Gugler R, Jensen JC "Interaction between cimetidine and metronidazole." N Engl J Med 309 (1983): 1518-9
Loft S, Dossing M, Sonne J, Dalhof K, Bjerrum K, Poulsen HE "Lack of effect of cimetidine on the pharmacokinetics and metabolism of a single oral dose of metronidazole." Eur J Clin Pharmacol 35 (1988): 65-8
Loft S, Sonne J, Poulsen HE, Peterson KT, Jorgensen BG, Dossing M "Inhibition and induction of metronidazole and antipyrine metabolism." Eur J Clin Pharmacol 32 (1987): 35-41

Cimetidine Tablets

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Tablets?

Flagyl 375

Generic Name: metronidazole

Brand name: FIRST Metronidazole, Flagyl, Flagyl 375, MetroGel

Synonyms: Flagyl 375 Capsules

What is Flagyl 375?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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