Cimetidine Tablets and Fosamax Plus D
Determining the interaction of Cimetidine Tablets and Fosamax Plus D and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Cimetidine may interfere with the metabolism of vitamin D to its biologically active form. The proposed mechanism is inhibition of hepatic hydroxylation. The clinical significance is unknown. It may be advisable to consider Vitamin D supplementation.
- Odes HS, Fraser GM, Krugliak P, et al "Effect of cimetidine on hepatic vitamin D metabolism in humans." Digestion 46 (1990): 61-4
- "Product Information. Fosamax Plus D (alendronate-cholecalciferol)." Merck & Company Inc, West Point, PA.
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: Cimetidine
Generic Name: alendronate / cholecalciferol
Brand name: Fosamax Plus D
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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