Cimetidine Tablets and Norpace CR

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

A small study (n=6) has reported that concurrent administration of oral disopyramide and cimetidine resulted in a 19% increase in the peak plasma concentration of disopyramide, a 9% increase in the area under the plasma concentration-time curve, and a 20% increase in the total amount of disopyramide excreted unchanged in the urine. (Cimetidine did not alter the absorption of a single 150 mg dose of disopyramide administered by an IV bolus.) The mechanism of this interaction may be an increase in the absorption of disopyramide caused by cimetidine. Patients should be monitored for evidence of an interaction.

Cimetidine Tablets

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Tablets?

Norpace CR

Generic Name: disopyramide

Brand name: Norpace, Norpace CR

Synonyms: n.a.

What is Norpace CR?