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Cimetidine Tablets and Seldane

Determining the interaction of Cimetidine Tablets and Seldane and the possibility of their joint administration.

Check result:

Cimetidine Tablets <> Seldane

Relevance: 15.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Terfenadine is no longer on the market in the US. Do not take terfenadine with any other medication.

Professional:

GENERALLY AVOID: Cimetidine inhibits the CYP450 isoenzymes and may interfere with metabolism of the antihistamines terfenadine and astemizole. The accumulation of either of these drugs may result in a prolongation of the QT interval and could lead to the development of ventricular arrhythmias such as torsades de pointes. One case of drug-induced torsades de pointes has been reported in a patient receiving cimetidine and terfenadine. The patient was also receiving other medications including chlorpheniramine, propoxyphene and acetaminophen. Cimetidine reportedly did not affect terfenadine pharmacokinetics or EKGs in a controlled study with 6 healthy subjects.

MANAGEMENT: Until more information is available, it may be best to avoid this combination. Cetirizine, fexofenadine, or loratadine may be safer antihistamine alternatives.

References

Ng PW, Chan WK, Chan TYK "Torsade de pointes during the concomitant use of terfenadine and cimetidine." Aust N Z J Med 26 (1996): 120-1
Woosley R, Carrow WR "Analysis of potential adverse drug reactions--a case of mistaken identity." Am J Cardiol 74 (1994): 208-9
Hey JA, Delprado M, Egan RW, Kreutner W "Terfenadine, astemizole, and ebastine produce QTc interval prolongation in an experimental model predictive of adverse clinical ECG effects." Ann Allergy Asthma Immunol 76 (1996): 476
Honig PK, Wortham DC, Zamani K, Conner DP, Mullin JC, Cantilena LR "Effect of concomitant administration of cimetidine and ranitidine on the pharmacokinetics and electrocardiographic effects of terfenadine." Eur J Clin Pharmacol 45 (1993): 41-6
Woosley RL, Chen Y, Freiman JP, Gillis RA "Mechanism of the cardiotoxic actions of terfenadine." JAMA 269 (1993): 1532-6

Cimetidine Tablets

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Tablets?

Seldane

Generic Name: terfenadine

Brand name: Seldane

Synonyms: n.a.

What is Seldane?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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