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Cimetidine Tablets and Tocainide

Determining the interaction of Cimetidine Tablets and Tocainide and the possibility of their joint administration.

Check result:
Cimetidine Tablets <> Tocainide
Relevance: 15.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Cimetidine decreases the bioavailability of tocainide in healthy subjects. The mechanism and clinical significance are unknown. Management consists of monitoring the patient's response to tocainide and consideration of checking plasma tocainide concentrations after 3 days of coadministration. Famotidine, nizatidine, and ranitidine are not expected to interact and may be considered as alternatives.

References
  • North DS, Mattern AL, Kapil RP, Lalonde RL "The effect of histamine-2 receptor antagonists on tocainide pharmacokinetics." J Clin Pharmacol 28 (1988): 640-3
Cimetidine Tablets

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

Tocainide

Generic Name: tocainide

Brand name:

Synonyms: Tocainide (Oral)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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