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Cimetidine Tablets and Valacyclovir

Determining the interaction of Cimetidine Tablets and Valacyclovir and the possibility of their joint administration.

Check result:

Cimetidine Tablets <> Valacyclovir

Relevance: 15.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Cimetidine may increase the serum concentration of acyclovir. The mechanism is competitive inhibition of the renal tubular secretion of acyclovir. Initial dosage adjustments usually are not necessary. Patients should, however, be monitored for acyclovir-related toxicities. Also, cimetidine reduces the rate at which valacyclovir is converted to acyclovir. The extent of conversion is unaffected, and this interaction is not considered to be clinically significant.

References

Rolan PE, Maillot F, On NT, Posner J "The effects of cimetidine and probenecid on the conversion of a valine ester of acyclovir, 256U, to acyclovir and acyclovir renal clearance in healthy volunteers." Br J Clin Pharmacol 33 (1993): 533
"Product Information. Valtrex (valacyclovir)." Glaxo Wellcome, Research Triangle Park, NC.

Cimetidine Tablets

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Tablets?

Valacyclovir

Generic Name: valacyclovir

Brand name: Valtrex

Synonyms: ValACYclovir

What is Valacyclovir?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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