Cipro Iv Minibags and Esbriet

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ciprofloxacin may significantly increase the blood levels of pirfenidone, especially if you are receiving a high dosage for a severe or serious infection. This can increase the risk and/or severity of side effects such as liver problems, sensitivity to sunlight, rash, dizziness, diarrhea, nausea, vomiting, and upset stomach. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with moderate inhibitors of CYP450 1A2 such as ciprofloxacin may increase the plasma concentrations of pirfenidone, which is primarily (70% to 80%) metabolized by the isoenzyme. In 27 healthy study subjects, administration of a single 801 mg dose of pirfenidone on day 6 of treatment with ciprofloxacin 750 mg twice daily increased pirfenidone peak plasma concentration (Cmax) and systemic exposure (AUC) by 23% and 81%, respectively.

MANAGEMENT: Caution is advised when pirfenidone is used with ciprofloxacin at a dosage of 1000 mg/day or less. Use with ciprofloxacin 1500 mg/day should be avoided if possible, otherwise a reduction of pirfenidone maintenance dosage to 534 mg three times a day is recommended. All patients receiving pirfenidone with ciprofloxacin should be closely monitored for adverse reactions such as hepatotoxicity, photosensitivity, rash, nausea, diarrhea, vomiting and dyspepsia, and consideration be given to dosage reduction, brief interruption, or permanent discontinuation of pirfenidone if clinically necessary in accordance with the product labeling.

Cipro Iv Minibags

Generic Name: ciprofloxacin

Brand name: Cipro IV, Cipro, Cipro XR, Proquin XR

Synonyms: Cipro I.V. (injection)

What is Cipro Iv Minibags?

Esbriet

Generic Name: pirfenidone

Brand name: Esbriet

Synonyms: n.a.

What is Esbriet?