Cipro Iv Minibags and Fazaclo

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ciprofloxacin may increase the blood levels and effects of cloZAPine. This can increase the risk and/or severity of side effects including seizures, low blood pressure, high blood sugar, diabetes, Parkinson-like symptoms, abnormal/uncontrollable muscle movements in the face and limbs, irregular heart rhythm, and agranulocytosis, which is a rare but serious and potentially fatal disorder that affects white blood cells. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you develop signs and symptoms of infection such as fever, chills, body aches, sore throat, coughing, breathing difficulties, mouth ulcers, or flu-like symptoms during treatment with cloZAPine. In addition, you should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: Coadministration with certain quinolone antibiotics may increase the plasma concentrations and the risk of adverse effects, including QT prolongation, of clozapine. The mechanism is inhibition of CYP450 1A2, the isoenzyme primarily responsible for the metabolic clearance of clozapine. Quinolones that may inhibit CYP450 1A2 include ciprofloxacin, enoxacin, grepafloxacin, nalidixic acid, norfloxacin, and perfloxacin (not all commercially available). In seven schizophrenia patients stabilized on clozapine therapy, ciprofloxacin (250 mg orally twice a day for 7 days) increased the mean serum concentration of clozapine and its pharmacologically active N-desmethyl metabolite by 29% and 31%, respectively, compared to placebo. There was a significant positive correlation between the individual serum concentrations of ciprofloxacin and the increase in concentrations of clozapine plus N-desmethylclozapine. A possible interaction with ciprofloxacin was also described in a 72-year-old man who had been receiving clozapine 18.75 mg/day for three months when presented to the behavioral ICU with agitation and behavioral disturbances. At the time of admission, his clozapine plasma level was 90 ng/mL and he was completing the last day of a 10-day course of ciprofloxacin. However, just prior to discharge and following completion of ciprofloxacin therapy, clozapine plasma concentration was undetectable. No other medication changes occurred while the patient was hospitalized.

MANAGEMENT: Pharmacologic response and plasma clozapine concentrations should be monitored more closely whenever certain quinolones such as ciprofloxacin or norfloxacin are added to or withdrawn from therapy, and the clozapine dosage adjusted as necessary.

Cipro Iv Minibags

Generic Name: ciprofloxacin

Brand name: Cipro IV, Cipro, Cipro XR, Proquin XR

Synonyms: Cipro I.V. (injection)

What is Cipro Iv Minibags?

Fazaclo

Generic Name: clozapine

Brand name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex

Synonyms: FazaClo

What is Fazaclo?