Cipro Iv Minibags and Foscavir

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Foscarnet may rarely cause seizures, and combining it with other medications that can also cause seizures such as ciprofloxacin may increase that risk. You may be more susceptible if you are elderly or have impaired kidney function, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumor or head trauma. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Limited data suggest that coadministration of foscarnet and ciprofloxacin may potentiate the risk of seizures. Both agents are individually epileptogenic and may have additive effects when combined. Specifically, foscarnet can decrease the seizure threshold by chelating ionized calcium and magnesium, while ciprofloxacin inhibits gamma-aminobutyric acid (GABA). In a published report, two patients with AIDS developed generalized tonic-clonic seizures while receiving foscarnet and ciprofloxacin for the treatment of cytomegalovirus (CMV) retinitis and disseminated Mycobacterium avium complex (MAC) infection, respectively. The first patient developed seizures both during the first and second dose of foscarnet (60 mg/kg every 8 hours) while being treated with ciprofloxacin (750 mg twice a day) and some other medications, but experienced no further seizures after discontinuation of foscarnet therapy. The second patient had been receiving foscarnet without incident until he was given ciprofloxacin and various other antimicrobial agents for MAC sepsis. Shortly thereafter, he developed seizures upon the start of a foscarnet infusion and when the infusion was restarted following a brief interruption. A study in mice also found increased seizure potential associated with the combination of foscarnet and ciprofloxacin.

MANAGEMENT: Caution is advised during coadministration of foscarnet and ciprofloxacin, particularly in elderly patients and those with renal impairment, electrolyte and metabolic abnormalities, or underlying neurologic disorders. The same precaution may be applicable during therapy with other quinolones, although clinical data are lacking.

Cipro Iv Minibags

Generic Name: ciprofloxacin

Brand name: Cipro IV, Cipro, Cipro XR, Proquin XR

Synonyms: Cipro I.V. (injection)

What is Cipro Iv Minibags?

Foscavir

Generic Name: foscarnet

Brand name: Foscavir

Synonyms: n.a.

What is Foscavir?