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Cipro Iv Minibags and Gengraf Capsules

Determining the interaction of Cipro Iv Minibags and Gengraf Capsules and the possibility of their joint administration.

Check result:

Cipro Iv Minibags <> Gengraf Capsules

Relevance: 14.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using ciprofloxacin together with cycloSPORINE can increase the effects of cycloSPORINE and cause damage to the kidneys or nerve loss. Tell your doctor if you experience dizziness, numbness, skin tingling, muscle twitching, or seizures which may be signs of nerve damage. Talk with your doctor if you develop fever, chills, body aches, flu symptoms, and severe pain in your upper stomach spreading to your back. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Ciprofloxacin may increase cyclosporine serum concentrations by an unknown mechanism. The risk of cyclosporine-induced neurotoxicity and nephrotoxicity may be increased. Acute renal failure, decreased renal function, and reversible nephrotoxicity have been reported. Several controlled studies have failed to demonstrate a pharmacokinetic interaction.

MANAGEMENT: If cyclosporine and ciprofloxacin are used together, cyclosporine levels and renal function, including serum creatinine, should be carefully monitored. Cyclosporine dosage should be adjusted as needed. Patients should be advised to notify their physician if they experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache.

References

Yee GC, McGuire TR "Pharmacokinetic drug interactions with cyclosporin (part II)." Clin Pharmacokinet 19 (1990): 400-15
Avent CK, Krinsky D, Kirklin JK, Bourge RC, Figg WD, "Synergistic nephrotoxicity due to ciprofloxacin and cyclosporine." Am J Med 85 (1988): 452-3
Nasir M, Rotellar C, Hand M, et al "Interaction between ciclosporin and ciprofloxacin." Nephron 57 (1991): 245-6
Hoey LL, Lake KD "Does ciprofloxacin interact with cyclosporine?" Ann Pharmacother 28 (1994): 93-6
Lang J, De-Villaine JF, Garraffo R, Touraine JL "Cyclosporine (cyclosporine A) pharmacokinetics in renal translant patients receiving ciprofloxacin." Am J Med 87 (1989): s82-5
Tan KK, Trull AK, Shawket S "Co-adminstration of ciprofloxacin and cyclosporin: lack of evidence for a pharmacokinetic interaction." Br J Clin Pharmacol 28 (1989): 185-7
Van Burne DH, Koestner J, Adedoyin A, et al "Effect of ciprofloxacin on cyclosporine pharmacokinetics." Transplantation 50 (1990): 888-9
Kruger HU, Schuler U, Proksch B, et al "Investigation of potential interaction of ciprofloxacin with cyclosporine in bone marrow transplant recipients." Antimicrob Agents Chemother 34 (1990): 1048-52

Cipro Iv Minibags

Generic Name: ciprofloxacin

Brand name: Cipro IV, Cipro, Cipro XR, Proquin XR

Synonyms: Cipro I.V. (injection)

What is Cipro Iv Minibags?

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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