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Cipro Iv Minibags and Levothyroxine oral/injection

Determining the interaction of Cipro Iv Minibags and Levothyroxine oral/injection and the possibility of their joint administration.

Check result:
Cipro Iv Minibags <> Levothyroxine oral/injection
Relevance: 14.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using ciprofloxacin together with levothyroxine can decrease the effects of levothyroxine. You should separate administration of ciprofloxacin and levothyroxine by several hours to minimize any effect this could have. Talk with your doctor before using ciprofloxacin while you are using levothyroxine. You may need a dose adjustment and you may need to check your thyroid more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Limited data suggest that simultaneous administration of oral ciprofloxacin may interfere with the gastrointestinal absorption of levothyroxine. The mechanism has not been described. In one case report, two elderly patients stabilized on levothyroxine therapy developed hypothyroidism three and four weeks after starting treatment with oral ciprofloxacin. Other concomitant medications were unchanged. In one of the patients, increasing the dosage of levothyroxine had no effect, and thyroid function tests normalized only after discontinuation of ciprofloxacin. In the other patient, thyroid function tests normalized soon after switching from concomitant administration of levothyroxine and ciprofloxacin to administration with a six hour gap.

MANAGEMENT: Although data are limited, it may be prudent to advise patients to separate administration of levothyroxine and ciprofloxacin by several hours to minimize the potential for interaction.

References
  • Cooper JG, Harboe K, Frost SK, Skadberg O "Ciprofloxacin interacts with thyroid replacement therapy." BMJ 330 (2005): 1002
Cipro Iv Minibags

Generic Name: ciprofloxacin

Brand name: Cipro IV, Cipro, Cipro XR, Proquin XR

Synonyms: Cipro I.V. (injection)

Levothyroxine oral/injection

Generic Name: levothyroxine

Brand name: Levoxyl, Synthroid, Tirosint, Unithroid, Euthyrox, Levothroid, Tirosint-Sol

Synonyms: Levothyroxine

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle