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Cipro Iv Minibags and Mexitil

Determining the interaction of Cipro Iv Minibags and Mexitil and the possibility of their joint administration.

Check result:

Cipro Iv Minibags <> Mexitil

Relevance: 14.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The coadministration of certain quinolone antibiotics and mexiletine may result in modestly elevated plasma concentrations of the latter. The proposed mechanism is inhibition of CYP450 1A2 hepatic metabolism of mexiletine. The clinical significance is unknown. Discontinuation or change of dosage may be necessary if an interaction is suspected.

References

McLellan RA, Drobitch RK, Monshouwer M, Renton KW "Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human." Drug Metab Dispos 24 (1996): 1134-8
Labbe L, Lefez C, Gilbert M, O'Hara G, Turgeon J "Ciprofloxacin (CIPRO) decreases mexiletine (MEX) clearance in smokers and non-smokers." Clin Pharmacol Ther 57 (1995): 210

Cipro Iv Minibags

Generic Name: ciprofloxacin

Brand name: Cipro IV, Cipro, Cipro XR, Proquin XR

Synonyms: Cipro I.V. (injection)

What is Cipro Iv Minibags?

Mexitil

Generic Name: mexiletine

Brand name: Mexitil

Synonyms: n.a.

What is Mexitil?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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