Cipro Iv Minibags and Sevelamer Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Sevelamer may interfere with the absorption of ciprofloxacin into the bloodstream and reduce its effectiveness. To minimize the potential for interaction, it has been recommended to separate the dosing of these medications by at least 4 hours. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Concurrent administration of sevelamer hydrochloride may decrease the oral bioavailability of ciprofloxacin and other quinolones, potentially reducing antibiotic efficacy and increasing the risk of bacterial resistance. The proposed mechanism is reduced quinolone absorption due to chelation with the protonated amine groups of sevelamer in the intestine. In 15 healthy volunteers, administration of sevelamer hydrochloride (7 X 403 mg capsules) followed immediately by a single dose of ciprofloxacin 750 mg resulted in decreased peak plasma concentration (Cmax) and relative oral bioavailability of ciprofloxacin by 27% and 48%, respectively, compared to administration of ciprofloxacin alone. The interaction was subject to a high degree of interindividual variation. Compared with ciprofloxacin alone, the relative oral bioavailability of ciprofloxacin ranged from 0.27 to 1.16 when coadministered with sevelamer. Two subjects had increased ciprofloxacin systemic exposure (AUC) with sevelamer. No data are available for other quinolones but a similar interaction should be expected.

MANAGEMENT: Oral quinolone antibiotics should not be administered simultaneously with sevelamer hydrochloride. The optimal length of time needed to separate ingestion of these drugs is currently unknown. Based on the fact that it took up to 4 hours to achieve ciprofloxacin Cmax in all 15 volunteers of the study, the authors suggested a separation time of at least 4 hours between sevelamer and ciprofloxacin administration to reduce the likelihood of a significant interaction, particularly in patients with end-stage renal disease whose gastrointestinal motility may be slowed.

Cipro Iv Minibags

Generic Name: ciprofloxacin

Brand name: Cipro IV, Cipro, Cipro XR, Proquin XR

Synonyms: Cipro I.V. (injection)

What is Cipro Iv Minibags?

Sevelamer Tablets

Generic Name: sevelamer

Brand name: Renagel, Renvela

Synonyms: Sevelamer

What is Sevelamer Tablets?