Cipro Iv Minibags and Sporanox (Itraconazole Capsules (Sporanox))

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ciprofloxacin can increase the blood levels and effects of itraconazole. Combining these medications may increase the frequency and/or severity of side effects such as nausea, vomiting, diarrhea, abdominal pain, and skin rash. You may also have an increased risk of developing rare, but serious side effects of itraconazole such as new or worsening heart failure, fluid retention, liver damage, nerve damage, or hearing loss. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience potential signs and symptoms of heart failure such chest pain; sudden, unexplained weight gain; swelling of the hands, ankles, or feet; shortness of breath; and/or difficulty breathing. You should also seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with ciprofloxacin may increase the plasma concentrations of itraconazole. The proposed mechanism is ciprofloxacin inhibition of the CYP450 3A4-mediated metabolism of itraconazole. In ten healthy male volunteers, administration of itraconazole (200 mg twice daily) in combination with ciprofloxacin (500 mg twice daily) for 7 days increased the mean itraconazole peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) by 53%, 82% and 86%, respectively, compared to administration of itraconazole alone. Conversely, itraconazole had no significant effect on the pharmacokinetics of ciprofloxacin. Adverse reactions reported in study subjects during combination treatment include nausea (60%), dry mouth (40%), diarrhea (10%), and headache (10%), none of which were reported during treatment with either agent alone.

MANAGEMENT: Clinical response to itraconazole should be closely monitored during coadministration with ciprofloxacin. A dosage reduction of itraconazole may be required to minimize the risk of adverse effects such as new onset or worsening congestive heart failure, peripheral or pulmonary edema, hepatotoxicity, peripheral neuropathy, and hearing loss.

Cipro Iv Minibags

Generic Name: ciprofloxacin

Brand name: Cipro IV, Cipro, Cipro XR, Proquin XR

Synonyms: Cipro I.V. (injection)

What is Cipro Iv Minibags?

Sporanox (Itraconazole Capsules (Sporanox))

Generic Name: itraconazole

Brand name: Onmel, Sporanox, Sporanox PulsePak, Tolsura

Synonyms: Itraconazole

What is Sporanox (Itraconazole Capsules (Sporanox))?