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Cipro Iv Minibags and Tasimelteon

Determining the interaction of Cipro Iv Minibags and Tasimelteon and the possibility of their joint administration.

Check result:
Cipro Iv Minibags <> Tasimelteon
Relevance: 14.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using tasimelteon together with ciprofloxacin is not recommended. Combining these medications may significantly increase the blood levels and effects of tasimelteon, which can lead to increased or prolonged drowsiness and breathing difficulties. Death may occur as a result of excessive tasimelteon levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with potent inhibitors of CYP450 1A2 may significantly increase the plasma concentrations of tasimelteon, which is primarily metabolized by the isoenzyme. When tasimelteon was administered after 6 days of treatment with the potent CYP450 1A2 inhibitor fluvoxamine 50 mg/day, tasimelteon peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 2- and 7-fold, respectively, compared to tasimelteon administered alone.

MANAGEMENT: Concomitant use of tasimelteon with potent CYP450 1A2 inhibitors such as fluvoxamine, ciprofloxacin, or enoxacin should be avoided.

References
  • "Product Information. Hetlioz (tasimelteon)." Vanda Pharmaceuticals Inc, Rockville, MD.
Cipro Iv Minibags

Generic Name: ciprofloxacin

Brand name: Cipro IV, Cipro, Cipro XR, Proquin XR

Synonyms: Cipro I.V. (injection)

Tasimelteon

Generic Name: tasimelteon

Brand name: Hetlioz

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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