Cipro Iv Minibags and Toprol XL

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

The coadministration of ciprofloxacin and metoprolol may result in elevated plasma concentrations of the latter. In seven healthy male subjects, ciprofloxacin (500 mg orally every 12 hours for 5 doses) increased the area under the plasma concentration-time curve (AUC) of a single oral dose of metoprolol (100 mg) by 54% for its less active (+) enantiomer and 29% for its more active (-) enantiomer. The oral clearance of (+) and (-) metoprolol was decreased by 38.5% and 12.5%, respectively. The mechanism by which ciprofloxacin may increase metoprolol plasma concentrations is unknown. Ciprofloxacin has not been shown to inhibit the CYP450 2D6 isoenzyme, which is responsible for the metabolism of metoprolol and several other beta-blockers. Since pharmacodynamic effects were not described in the study, the clinical significance of the interaction is also unclear. Until further data are available, it may be appropriate to monitor patients for potentially increased pharmacologic effects of metoprolol during concomitant therapy with ciprofloxacin. Patients should be advised to notify their physician if they experience possible symptoms of increased beta blockade such as fainting, swelling of the extremities, weight gain, or slow pulse.

Cipro Iv Minibags

Generic Name: ciprofloxacin

Brand name: Cipro IV, Cipro, Cipro XR, Proquin XR

Synonyms: Cipro I.V. (injection)

What is Cipro Iv Minibags?

Toprol XL

Generic Name: metoprolol

Brand name: Toprol-XL, Lopressor, Kapspargo Sprinkle, Toprol XL

Synonyms: Toprol-XL

What is Toprol XL?